Peptic Ulcers Caused by Pain Relievers

Peptic ulcers (ULSERS) are sores that form in the lining of the stomach and sometimes the duodenum. The duodenum is the first part of the small intestine. Most peptic ulcers are caused by infection with the bacteria called helicobacter pylori (H. pylori). However, long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) can also cause a person to have peptic ulcer. NSAIDs include aspirin, ibuprofen, and naproxen sodium.

The most common symptom of peptic ulcer is a gnawing, burning pain in the upper abdomen. Other symptoms of peptic ulcer may include
 loss of appetite

 weight loss

 fatigue

 nausea

 vomiting
The stomach has its own protective mechanisms against the stomach’s digestive juices. However, NSAIDs can hinder with these protective mechanisms lowering the stomach’s defenses. As a result, the digestive juices can damage the stomach wall causing ulcers.

Peptic ulcers can get worse if not treated. The peptic ulcer caused by NSAIDs usually starts to heal once the person stops taking the medication. Sometimes, medications may be prescribed to protect the stomach lining or antibiotics to kill the ulcer-causing bacteria. In some cases, surgery may be needed for ulcers that don’t heal.

Related Readings:
Peptic Ulcers and NSAIDs
Peptic Ulcer


References:
National Digestive Diseases Information Clearinghouse (NDDIC), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health. NIH Publication No. 04–4644, September 2004

MedlinePlus ( October 2009). Peptic Ulcer. National Library of Medicine, National Institutes of Health.


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